in spite of后面加is还是are

in spite of+名词、代词、名词性从句（宾语从句）。如：He stuck to his own opinion in spite of what I had said.

例句，In spite of his age， he still leads an active life.

尽管年事已高，他依旧过着一种忙碌的生活。

She is still very active， in spite of her advancing years.

她尽管年事渐高，仍然十分活跃。